Pharmacology & ToxicologybioRxiv
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity
J. Mobbs, M. J. Belousoff, K. G. Harikumar…·P. M. Sexton
The paper determines cryo-EM structures of the CCK1R bound to Gs and Gq proteins, revealing conformational changes that enable promiscuous G protein coupling.