Author

D. M. Thal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Assay:cryo-EM· 4 Research Focus:protein structure prediction· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Christopoulos· 4 shared A. Glukhova· 3 shared C. Valant· 3 shared H. Venugopal· 3 shared J. I. Mobbs· 3 shared C. W. Lindsley· 2 shared D. Wootten· 2 shared E. T. van der Westhuizen· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersPharmacology & Toxicology

A. Christopoulos

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Author profile →

7 papers

Recent·Most cited

Structural insights into the human P2X1 receptor and ligand interactions

F. Bennetts, H. Venugopal, A. Glukhova, J. I. Mobbs, S. Ventura, D. M. Thal

This study determines the structure of the human P2X1 receptor in different ligand-bound states and identifies key residues involved in ligand binding and selectivity.

bioRxiv · Apr 4, 2024Pharmacology & Toxicology

Positive allosteric modulation of a GPCR ternary complex

W. Burger, C. Draper-Joyce, C. Valant, A. Christopoulos, D. M. Thal

This study shows positive allosteric modulators stabilize the GPCR-G protein ternary complex, enhancing signaling when nucleotides are present.

bioRxiv · Apr 4, 2024Pharmacology & Toxicology

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

J. I. Mobbs, K. A. Black, M. Tran, H. Venugopal, T. R. Holman, M. Holinstat, D. M. Thal, A. Glukhova

This study determines the cryo-EM structures of human 12-LOX, revealing its oligomeric states, catalytic mechanism, and inhibitor binding, which informs drug development.

bioRxiv · Mar 10, 2023Biochemistry

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Z. Vuckovic, J. Wang, V. Pham, J. I. Mobbs, M. J. Belousoff, A. Bhattarai, W. A. C. Burger, G. Thompson, M. Yeasmin, K. Leach, E. T. van der Westhuizen, E. Khajehali, Y.-L. Liang, A. Glukhova, D. Wootten, , D. M. Thal

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

bioRxiv · Sep 27, 2022Pharmacology & Toxicology

Selective G protein signaling driven by Substance P-Neurokinin Receptor structural dynamics

J. A. Harris, B. Faust, A. B. Gondin, M. A. Damgen, C.-M. Suomivuori, N. A. Veldhuis, Y. Cheng, R. O. Dror, D. M. Thal, A. Manglik

This study investigates how different agonists of the NK1R receptor influence G-protein signaling through structural dynamics and extracellular loop interactions.

bioRxiv · May 16, 2021Biochemistry

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity

J. Mobbs, M. J. Belousoff, K. G. Harikumar, S. J. Piper, X. Xu, S. G. B. Furness, H. Venugopal, A. Christopoulos, R. Danev, D. Wootten, D. M. Thal, L. J. Miller, P. M. Sexton

The paper determines cryo-EM structures of the CCK1R bound to Gs and Gq proteins, revealing conformational changes that enable promiscuous G protein coupling.

bioRxiv · May 6, 2021Pharmacology & Toxicology

Crystal structure of the M5 muscarinic acetylcholine receptor

Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.

bioRxiv · Aug 14, 2019Pharmacology & Toxicology