Selectively expressing SARS-CoV-2 Spike protein S1 subunit in cardiomyocytes induces cardiac hypertrophy in mice.
S. G. Negron, C. W. Kessinger, B. Xu, W. T. Pu, Z. Lin
This study shows that expressing SARS-CoV-2 Spike S1 subunit in cardiomyocytes causes cardiac hypertrophy and inflammation via TLR4 activation, independent of ACE2.
bioRxiv · Jun 20, 2021 · PreprintPathology