A prebiotic genetic alphabet as an early Darwinian ancestor for pre-RNA evolution
A. A. Sawant, S. Tripathi, S. Galande, S. Rajamani
This study synthesizes a prebiotic genetic alphabet with barbituric acid and demonstrates its enzymatic incorporation into RNA and transfer to DNA, suggesting a pathway for early genetic code evolution.
bioRxiv · Mar 16, 2023 · PreprintBiochemistry