A. Shetty

Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

This study shows that prior exposure to saprophytic Leptospira reduces severe leptospirosis symptoms and kidney fibrosis when mice are later infected with a pathogenic serovar.

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.

This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.

Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumours

This study compares FAP-targeted MRI with PSMA-targeted MRI for delineating prostate tumors in mice, finding FAP provides better contrast enhancement.

Measuring the metabolic evolution of glioblastoma throughout tumor development, regression, and recurrence with hyperpolarized magnetic resonance

This study uses hyperpolarized MRI to track metabolic changes in glioblastoma across development, regression, and recurrence, showing its superior sensitivity compared to conventional MRI.

In-depth sequence-function characterization reveals multiple paths to enhance phenylalanine ammonia-lyase (PAL) activity.

This study identifies sequence-function relationships in PAL through deep mutational scanning and characterizes mechanisms of activity enhancement.

Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms

This study identifies allele-specific epigenetic activity in prostate cancer and normal tissue, linking it to GWAS risk loci and highlighting tumor-specific regulatory elements.

Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells

The paper identifies novel protein interaction networks of FOSL1 and FOSL2 in human Th17 cells using affinity purification-mass spectrometry, revealing new mechanistic links to RNA binding and Th17 cell differentiation.

The AP-1 factors FOSL1 and FOSL2 co-regulate human Th17 responses

The paper investigates the roles of FOSL1 and FOSL2 in human Th17 cell differentiation and finds they inhibit Th17 identity and interact with BATF to regulate gene expression.