Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER+ breast cancer cells.
N. Sabherwal, A. Rowntree, E. Marinopoulou, T. Pettini, S. Hourihane, R. Thomas, J. Kursawe, X. Soto, N. Papalopulu
The paper investigates Hes1 oscillations in ER+ breast cancer cells, showing that phase shifts in these oscillations relative to mitosis correlate with cell-cycle length heterogeneity and cancer stem cell properties.
bioRxiv · Jan 4, 2021Cell Biology