The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae
M. P. Motley, E. Diago-Navarro, K. Banerjee, S. Inzerillo, B. C. Fries
This study compares the efficacy of murine IgG1 and IgG3 monoclonal antibodies against CR-Kp, finding that IgG3 has superior complement-mediated and neutrophil-mediated activity, while IgG1 improves macrophage phagocytosis.
bioRxiv · Jul 24, 2020Immunology