Intravital multi-modal flux analysis reveals the transport mechanism of bile acids through hepatic microconduits
N. Vartak, G. Guenther, F. Joly, A. Damle-Vartak, G. Wibbelt, J. Fickel, S. Jörs, B. Begher-Tibbe, A. Friebel, K. Wansing, A. Ghallab, M. Rosselin, N. Boissier, I. Vignon-Clementel, C. Hedberg, , J. G. Hengstler
The paper develops two techniques to quantify bile acid transport in liver microdomains, revealing diffusion in canaliculi and advection in ducts.
bioRxiv · Jun 4, 2020Physiology