Multiscale Characterization of Complex Binding Interactions of Cellulolytic Enzymes Highlights Limitations of Classical Approaches
S. P. S. Chundawat, B. Nemmaru, M. Hackl, S. K. Brady, M. A. Hilton, M. M. Johnson, S. Chang, M. J. Lang, H. Huh, S.-H. Lee, J. M. Yarbrough, C. A. Lopez, S. Gnanakaran
This study uses single-molecule assays and simulations to show how CBM1 binding affects cellulase activity on different cellulose allomorphs, highlighting limitations of classical binding models.
bioRxiv · May 8, 2020 · PreprintBiochemistry