M. J. Lang

Parsing digital or analogue TCR performance through piconewton forces

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

Asymmetric framework motion of TCR alpha beta controls load-dependent peptide discrimination

The paper uses molecular dynamics simulations to show how asymmetric motion of TCR alpha beta chains affects peptide discrimination under mechanical force.

Weight loss improves skeletal muscle mitochondrial energy efficiency

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

The paper shows that preTCR-pMHC interactions prevent thymocyte dedifferentiation by analyzing single-cell transcriptomes in fetal thymic cultures with and without pMHC.

A kinesin-1 variant reveals motor-induced microtubule damage in cells

This study shows a kinesin-1 variant causes microtubule damage in cells, leading to breakage and fragmentation, suggesting evolutionary pressure against such variants.

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

Multiscale Characterization of Complex Binding Interactions of Cellulolytic Enzymes Highlights Limitations of Classical Approaches

This study uses single-molecule assays and simulations to show how CBM1 binding affects cellulase activity on different cellulose allomorphs, highlighting limitations of classical binding models.

Plasma-derived HIV Nef+ exosomes persist in ACTG384 study participants despite successful virological suppression.

The paper measures Nef+ exosomes in HIV+ patients on ART and finds they persist despite viral suppression and correlate with CD4 recovery patterns.