Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors
R. Devarajan, H. Peltoketo, V. Izzi, H. J. Ruotsalainen, S. Kauppila, M.-R. Vaisanen, G. Rask, G. Martinez-Nieto, S.-M. Karppinen, T. Vaisanen, I. Kaur, J. P. Koivunen, T. Sasaki, R. Winqvist, F. Warnberg, , R. Heljasvaara
This study shows that collagen XVIII promotes breast cancer via EGFR/ErbB signaling and sustains cancer stem cells, and its inhibition enhances the effectiveness of ErbB-targeting therapies.
bioRxiv · Jan 10, 2022 · PreprintCancer Biology