Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes
C. Company, M. J. Schmitt, Y. Dramaretska, S. Kertalli, B. Jiang, M. Serresi, I. Barozzi, G. Gargiulo
The paper introduces LSD, a computational framework for designing synthetic cis-regulatory DNA to mark cellular states, and demonstrates its effectiveness in identifying cell-state drivers.
bioRxiv · Nov 4, 2022Bioengineering