Functional Optimization of Light-Activatable Opto-GPCRs: Illuminating the Importance of the Proximal C-terminus in G-protein Specificity
This study investigates the role of the proximal C-terminus and intracellular loop 3 in G-protein specificity using OptoGPCR chimeras, revealing distinct mechanisms in melanopsin-mGluR6 and rhodopsin-beta2-adrenoceptor.
bioRxiv · Jan 27, 2023Cell Biology