Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation
S. Koc-Gunel, E. C. Liu, L. K. Gautam, B. A. Calvert, S. Murthy, N. C. Harriott, J. C. Nawroth, B. Zhou, V. P. Krymskaya, A. L. Ryan
The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.
bioRxiv · Jun 12, 2023 · PreprintCell Biology