Author

J. C. Nawroth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. L. Ryan· 3 shared D. Roth· 3 shared A. Shukla· 2 shared A. van Schadewijk· 2 shared E. Kanso· 2 shared F. Ling· 2 shared G. Hamilton· 2 shared K. Karalis· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

A. L. Ryan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structure-function relationships of mucociliary clearance in human and rat airways

D. Roth, A. T. Sahin, F. Ling, N. Tepho, C. Senger, E. Quiroz, B. Calvert, A. van der Does, T. G. Güney, S. Glasl, A. van Schadewijk, L. von Schledorn, R. Olmer, E. Kanso, J. C. Nawroth, A. L. Ryan

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

bioRxiv · Dec 24, 2023Biophysics

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation

S. Koc-Gunel, E. C. Liu, L. K. Gautam, B. A. Calvert, S. Murthy, N. C. Harriott, J. C. Nawroth, B. Zhou, V. P. Krymskaya, A. L. Ryan

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

bioRxiv · Jun 12, 2023 · PreprintCell Biology

Primary Ciliary Dyskinesia patient specific hiPSC-derived airway epithelium in Air Liquid Interface culture recapitulates disease specific phenotypes in vitro

L. von Schledorn, D. P. Martin, N. Cleve, J. Zoellner, D. Roth, B. O. Staar, J. Hegermann, F. Ringshausen, J. C. Nawroth, U. Martin, R. Olmer

The paper develops an in vitro model of PCD using hiPSC-derived airway epithelium that recapitulates disease-specific phenotypes.

bioRxiv · Apr 25, 2023 · PreprintBioengineering

Flow Physics Explains Morphological Diversity of Ciliated Organs

F. Ling, T. Essock-Burns, M. McFall-Ngai, K. Katija, J. C. Nawroth, E. Kanso

The paper shows that ciliated organ designs follow functional constraints, connecting carpet and flame types through lumen diameter and cilia-to-lumen ratio.

bioRxiv · Feb 12, 2023Biophysics

Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations

J. C. Nawroth, C. Giez, A. Klimovich, E. A. Kanso, T. C. Bosch

The paper shows that spontaneous body wall contractions in Hydra enhance fluid transport, shaping host-microbe associations and modulating microbial spatial distribution.

bioRxiv · Nov 30, 2022Biophysics

Breathing on Chip: Dynamic flow and stretch tune cellular composition and accelerate mucociliary maturation of airway epithelium in vitro

J. C. Nawroth, D. Roth, A. van Schadewijk, A. Ravi, T. I. Maulana, C. N. Senger, S. van Riet, D. K. Ninaber, D. Kraft, P. S. Hiemstra, A. L. Ryan, A. M. van der Does

This study shows that applying airflow and stretch to airway epithelial cultures on a chip accelerates mucociliary maturation and alters cellular composition to better mimic airway biology.

bioRxiv · May 7, 2021 · PreprintCell Biology

Modeling alcoholic liver disease in a human Liver-Chip

J. C. Nawroth, D. B. Petropolis, D. V. Manatakis, T. I. Maulana, G. Burchett, K. Schluender, A. Witt, A. Shukla, G. Hamilton, E. Seki, S. Lu, K. Karalis

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

bioRxiv · Jul 14, 2020 · PreprintBioengineering

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

J. C. Nawroth, C. Lucchesi, D. Cheng, A. Shukla, J. Nguyen, T. Shroff, K. Karalis, H.-H. Lee, S. Alves, G. Hamilton, M. Salmon, R. Villenave

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

bioRxiv · Feb 2, 2020Bioengineering