PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1
S. Kant, K.-V. Tran, M. Kvandova, A. D. Caliz, H.-J. Yoo, H. Learnard, S. M. Craige, J. D. Hall, J. M. Jimenez, C. St. Hilaire, E. Schulz, S. Kroller-Schon, J. F. Keaney
This study identifies a PGC-1-TERT-HMOX1 axis that regulates endothelial response to laminar fluid shear stress, promoting alignment and stability.
bioRxiv · May 26, 2021Cell Biology