Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding
K. Nguyen, K. Li, K. Flores, G. Tomaras, S. M. Dennison, J. McCarthy
This paper develops a method for analyzing bivalent analyte binding kinetics in high-throughput SPR data, improving parameter estimation and identifiability through grid search and profile likelihood analysis.
bioRxiv · Dec 5, 2022Biophysics