Author

K. Flores

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. E. Comstock· 2 shared L. Garcia-Bayona· 2 shared M. J. Coyne· 2 shared A. Cabral· 1 shared A. G. Camacho· 1 shared A. J. Obregon-Tito· 1 shared A. Q. Holst· 1 shared A. R. Parab· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

L. E. Comstock

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

L. Garcia-Bayona, N. Said, M. J. Coyne, K. Flores, N. M. Elmekki, M. Sheahan, A. G. Camacho, K. Hutt, F. H. Yildiz, A. T. Kovacs, M. K. Waldor, L. E. Comstock

The paper identifies a large conjugative plasmid that promotes multispecies biofilm formation in the gut microbiota, enhancing resilience to environmental stressors.

bioRxiv · Apr 29, 2024 · PreprintMicrobiology

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype

X. Gong, N. Ogino, M. F. Leite, Z. Chen, R. Liu, E. Kruglov, K. Flores, A. Cabral, G. M. M. Mendes, B. E. Ehrlich, M. Mak

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.

bioRxiv · Oct 8, 2023 · PreprintCancer Biology

A ubiquitous mobile genetic element disarms a bacterial antagonist of the gut microbiota

M. L. Sheahan, M. J. Coyne, K. Flores, L. Garcia-Bayona, M. Chatzidaki-Livanis, A. Sundararajan, A. Q. Holst, B. Barquera, L. E. Comstock

The paper shows that a mobile genetic element inverts the antagonistic behavior of Bacteroides fragilis by disabling its native system and enhancing fitness through a new weapon.

bioRxiv · Aug 25, 2023 · PreprintMicrobiology

Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding

K. Nguyen, K. Li, K. Flores, G. Tomaras, S. M. Dennison, J. McCarthy

This paper develops a method for analyzing bivalent analyte binding kinetics in high-throughput SPR data, improving parameter estimation and identifiability through grid search and profile likelihood analysis.

bioRxiv · Dec 5, 2022Biophysics

The Core Human Fecal Metabolome

J. Haffner, M. Katemauswa, T. S. Kagone, E. Hossain, D. Jacobson, K. Flores, A. R. Parab, A. J. Obregon-Tito, R. Y. Tito, L. Marin Reyes, L. Troncoso-Corzo, E. Guija-Poma, N. Meda, H. Carabin, T. P. Honap, , L.-I. McCall

This study characterizes the core human fecal metabolome through untargeted metabolomic analysis of populations along an industrialization gradient, revealing shared and industrialization-related metabolites.

bioRxiv · May 8, 2021Biochemistry