Author

S. M. Soucy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

A. E. Goen· 1 shared A. Jiang· 1 shared A. L. Johnson· 1 shared A. M. Roberts· 1 shared B. A. Romo· 1 shared D. Schultz· 1 shared E. Demidenko· 1 shared E.-C. K. Duffy· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. E. Goen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamics of drug delivery determines course of evolution of antibiotic responses in bacteria

J. C. Crow, H. Geng, T. J. Sullivan, S. M. Soucy, D. Schultz

This study shows that the dynamics of antibiotic exposure influence the type of mutations that evolve in bacteria, with gradual exposure leading to adaptive mutations and periodic exposure causing loss of regulatory control.

bioRxiv · Nov 29, 2023 · PreprintMicrobiology

Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

N. A. Traphagen, G. N. Schwartz, S. Tau, A. Jiang, S. R. Hosford, A. E. Goen, A. M. Roberts, B. A. Romo, A. L. Johnson, E.-C. K. Duffy, E. Demidenko, P. Heverly, Y. Mosesson, S. M. Soucy, F. Kolling, T. W. Miller

This study shows estrogen therapy induces DNA damage in ER+ breast cancer cells, which can be enhanced by PARP inhibition to improve treatment outcomes.

bioRxiv · Mar 16, 2023Cancer Biology

Non-phylogenetic identification of co-evolving genes for reconstructing the archaeal Tree of Life

L. T. Rangel, S. M. Soucy, J. C. Setubal, J. P. Gogarten, G. P. Fournier

This paper introduces the Evolutionary Similarity Index (IES) to identify co-evolving gene families in archaea, finding eight major clusters with compatible evolutionary trends and evidence of horizontal gene transfer.

bioRxiv · Oct 16, 2020 · PreprintEvolutionary Biology

Insights into Origin and Evolution of α-proteobacterial Gene Transfer Agents

M. Shakya, S. M. Soucy, O. Zhaxybayeva

This study investigates the origin and evolution of RcGTA in α-proteobacteria, finding that it co-evolves with host chromosomes and is not an atypical or defective virus.

bioRxiv · Oct 29, 2017Evolutionary Biology