S. Mana-Capelli

The ability of the LIMD1 and TRIP6 LIM domains to bind to f-actin under strain is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1.

This study shows that TRIP6 and LIMD1 bind to strained actin, enabling their localization to adherens junctions and interaction with LATS1, a key Hippo pathway kinase.

Multicellular Aligned Bands Disrupt Global Collective Cell Behavior

This study investigates how local cell-cell interactions in multicellular aggregates disrupt global collective cell behavior through the formation of aligned bands.

TRIP6 inhibits the Hippo signaling pathway in response to tension at adherens junctions

This study identifies TRIP6 as a mechanotransduction component that inhibits Hippo signaling by blocking LATS1/2 activation in response to tension at adherens junctions.