Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology and Target Identification of Thio-wurtzine, a Potent Inhibitor of the Opioid Receptors and the Voltage-Dependent Calcium Channels
S. Aguero, S. Megy, R. Terreux, M. Fournier, D. Kulagina, S. Sysolyatin, A. Kalashnikov, S. Krylova, A. Vorozhtsov, V. Zhdanov
This paper identifies thiowurtzine, a novel non-narcotic analgesic derived from CL-20, showing analgesic effects and targeting opioid receptors and voltage-gated calcium channels.
bioRxiv · Mar 18, 2021Pharmacology & Toxicology