M. Fournier

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax

This study identifies GLIS2 as a driver of pediatric AMKL and shows its sensitivity to navitoclax, offering a potential therapeutic strategy.

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease

This study shows that combining IL-2 mutein with ImmTOR nanoparticles expands antigen-specific Tregs and protects against autoimmune diseases.

The RPA complex orchestrates K63-linked deubiquitination via ZUP1

The paper shows that ZUP1 interacts with the RPA complex to enhance its K63-linked deubiquitination activity during DNA repair.

Combined SPT and FCS methods highlight a mechanism of RNAP II oversampling in cell nuclei

The paper combines SPT and FCS to study RNAP II motility, revealing different diffusion states and oversampling of nuclear subdomains, proposing a new model of transcription regulation.

Ubiquitin-based pathway acts inside chloroplasts to regulate photosynthesis

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology and Target Identification of Thio-wurtzine, a Potent Inhibitor of the Opioid Receptors and the Voltage-Dependent Calcium Channels

This paper identifies thiowurtzine, a novel non-narcotic analgesic derived from CL-20, showing analgesic effects and targeting opioid receptors and voltage-gated calcium channels.

mTOR repression in response to amino acid starvation promotes ECM degradation through MT1-MMP endocytosis arrest

The paper shows that mTOR repression during amino acid starvation leads to increased ECM degradation via MT1-MMP endocytosis arrest in tumor cells.

Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

Modelling the spatial crosstalk between two biochemical signals explains wood formation dynamics and tree-ring structure

A dynamical model shows that two interacting signals, auxin and cytokinin/TDIF, can explain wood formation dynamics and tree-ring structure in conifers.

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

This study shows that KAT2A/B acetylates PALB2 to regulate its chromatin association, enhancing DNA repair and genome stability.