VHL Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens
N. Sun, S. Petiwala, C. Lu, J. E. Hutti, M. Hu, M. Hu, M. H. Domanus, D. Mitra, S. N. Addo, C. P. Miller, N. Chung
The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.
bioRxiv · Mar 26, 2019Cancer Biology