Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-associated Excitable Cells
G. B. Borja, H. Zhang, B. N. Harwood, J. Jacques, J. Grooms, R. Chantre, D. Zhang, A. Barnett, C. A. Werley, Y. Lu, S. Nagle, O. B. McManus, G. T. Dempsey
The paper introduces the Swarm, a high-throughput optogenetic platform for screening ion channel modulators in excitable cells, demonstrating its utility in drug discovery for nervous system disorders and cardiac toxicity.
bioRxiv · Apr 11, 2022 · PreprintBioengineering