Author

S. O Conchuir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. Kortemme· 2 shared C. Krivacic· 1 shared J. E. Lucas· 1 shared J. J. Gray· 1 shared J. R. Jeliazkov· 1 shared J. S. Fraser· 1 shared K. A. Barlow· 1 shared K. Kundert· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

T. Kortemme

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2 papers

Recent·Most cited

Accurately positioning functional residues with robotics-inspired computational protein design

C. Krivacic, K. Kundert, X. Pan, R. A. Pache, L. Liu, S. O Conchuir, J. R. Jeliazkov, J. J. Gray, M. C. Thompson, J. S. Fraser, T. Kortemme

This paper introduces two computational methods for accurately positioning functional residues in proteins and validates them by redesigning enzyme active sites.

bioRxiv · Jul 2, 2021 · PreprintBioengineering

Flex ddG: Rosetta ensemble-based estimation of changes in protein-protein binding affinity upon mutation

K. A. Barlow, S. O Conchuir, S. Thompson, P. Suresh, J. E. Lucas, M. Heinonen, T. Kortemme

The paper introduces flex ddG, a method using Rosetta to estimate binding affinity changes upon mutation by sampling conformational diversity, and shows it outperforms existing methods in several mutation types.

bioRxiv · Nov 17, 2017Biophysics