P. Suresh

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

This study shows that Aβ aggregates trigger TLR4 less efficiently than LPS due to slower Myddosome formation and longer lifetimes of larger Myddosomes.

A semiconductor 96-microplate platform for real-time impedance-based high-throughput screening

This paper introduces a semiconductor microplate platform for real-time impedance-based high-throughput screening, demonstrating its ability to profile compound mechanisms of action across diverse cell types.

Lipid Driven Inter-leaflet Coupling of Plasma Membrane Order Regulates FcεRI Signaling in Mast Cells

This study shows that lipid-driven interleaflet coupling in mast cell membranes regulates FcεRI signaling by modulating inner leaflet order through outer leaflet lipid exchange.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

The paper models k-fiber anchorage in mammalian spindles and shows that spatially regulated anchorage creates distinct mechanical behaviors.

The Astrin/SKAP Complex Reduces Friction at the Kinetochore-Microtubule Interface

The paper investigates the role of the Astrin-SKAP complex in reducing friction at the kinetochore-microtubule interface, enhancing attachment dynamics and force responsiveness.

LOSS OF PLASMA MEMBRANE LIPID ASYMMETRY CAN INDUCE ORDERED DOMAIN (RAFT) FORMATION

The paper shows that loss of plasma membrane lipid asymmetry can induce ordered domain formation in PMVs, suggesting dynamic asymmetry control regulates raft stability.

Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered domains (rafts)

This study uses lipid exchange to show that insulin receptor activity depends on both bilayer width and ordered domain formation in the plasma membrane.

Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure

This study uses microneedles to apply force to kinetochore-fibers and shows how they dissipate force to maintain spindle structure.

Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

The paper uses microneedle manipulation to study spindle reinforcement, finding short-lived, specialized structures near chromosomes that require PRC1.

qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

qFit-ligand identifies unmodeled ligand conformations in crystal structures, revealing 29% of drug-like molecules exhibit conformational heterogeneity that could improve drug design.

Flex ddG: Rosetta ensemble-based estimation of changes in protein-protein binding affinity upon mutation

The paper introduces flex ddG, a method using Rosetta to estimate binding affinity changes upon mutation by sampling conformational diversity, and shows it outperforms existing methods in several mutation types.