The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines
K. Nagashima, J. V. Dzimianski, J. Han, N. Abbadi, A. D. Gingerich, F. Royer, S. O'Rourke, G. A. Sautto, T. M. Ross, A. B. Ward, R. M. DuBois, J. Mousa
This study identifies pre-existing human B cell responses to computationally optimized H1 hemagglutinin vaccines, showing cross-reactivity and functional antibodies targeting head, central stalk, and anchor epitopes.
bioRxiv · Oct 25, 2021Immunology