Pre-Steady-State Kinetic Characterization of an Antibiotic-Resistant Mutation of Staphylococcus aureus DNA Polymerase PolC
R. Nelson-Rigg, S. P. Fagan, W. J. Jaremko, J. D. Pata
This paper characterizes the kinetic effects of an antibiotic-resistant mutation in Staphylococcus aureus DNA polymerase PolC, showing reduced drug binding and replication efficiency.
bioRxiv · Oct 4, 2022 · PreprintBiochemistry