MicrobiologybioRxiv
ADEP1 activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles' heel to deregulate proteostasis and hamper the cell survival
A. Dhara, M. S. Hussain, S. P. Kanaujia, M. Kumar
This study shows ADEP1 activates Leptospira ClpP1P2, disrupting proteostasis and inhibiting growth by altering peptidase activity and enabling proteolytic degradation of unfolded proteins.
DOI 10.1016/j.resmic.2021.103797