A cell-autonomous PD-1/PD-L1 circuit promotes tumorigenicity of thyroid cancer cells by activating a SHP2/Ras/MAPK signalling cascade
F. Liotti, N. Kumar, N. Prevete, M. Marotta, D. Sorriento, C. Ierano, A. Ronchi, F. Zito Marino, S. Moretti, R. Colella, E. Puxeddu, S. Paladino, Y. Kano, M. Ohh, S. Scala, R. M. Melillo
This study shows PD-1 in thyroid cancer cells promotes tumorigenicity via SHP2/Ras/MAPK signaling, and blocking this circuit inhibits tumor growth.
bioRxiv · Sep 22, 2020 · PreprintCancer Biology