Mass extravasation and tubular uptake of red blood cells results in toxic injury to the tubules during kidney ischemia from venous clamping
S. R. McLarnon, C. Johnson, J. Sun, Q. Wei, G. Csanyi, P. O'Herron, B. Marshall, J. C. Sullivan, A. Barrett, P. M. O'Connor
This study shows that venous clamping in rats causes severe kidney tubular injury due to red blood cell extravasation and uptake, which is absent in blood-free kidneys.
bioRxiv · Mar 31, 2022 · PreprintPhysiology