α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes
A. M. Suominen, G. Saldo Rubio, S. Ruohonen, Z. Szabo, L. Pohjolainen, B. Ghimire, S. T. Ruohonen, K. Saukkonen, J. Ijas, S. Skarp, L. Kaikkonen, M. Cai, S. L. Wardlaw, H. Ruskoaho, V. Talman, , P. Rinne
This study shows that α-MSH protects against cardiac remodeling by activating MC5-R in cardiomyocytes, suggesting potential therapeutic use of its analogs in heart failure.
bioRxiv · Apr 6, 2023 · PreprintPhysiology