Cell BiologybioRxiv
Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
B.-C. Lee, A. Gin, C. Wu…·C. Dunbar
This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.
DOI 10.1016/j.stem.2024.02.010