Membrane lipid reshaping underlies oxidative stress sensing by the mitochondrial proteins UCP1 and ANT1
O. Jovanovic, K. Chekashkina, S. Skulj, K. Zuna, M. Vazdar, P. V. Bashkirov, E. E. Pohl
The paper shows that oxidative stress alters lipid curvature, enhancing UCP1 and ANT1 protonophoric activity by reducing stored curvature elastic stress in membranes.
bioRxiv · Jul 6, 2022Biophysics