Single-cell analysis reveals the KIT D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis
J. Grootens, J. S. Ungerstedt, M. Ekoff, E. Rönnberg, M. Klimkowska, R.-M. Amini, M. Arock, S. Söderlund, M. Mattsson, G. Nilsson, J. S. Dahlin
This study identifies the KIT D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis, showing it is present in nearly all mast cells and spans the hematopoietic lineage.
bioRxiv · Jan 22, 2019Immunology