Stromal inflammation is a targetable driver of hematopoietic aging
E. V. Verovskaya, C. A. Mitchell, F. J. Calero-Nieto, A. Herault, P. D. Dellorusso, X. Wang, S. Y. Zhang, A. Flohr Svendsen, E. M. Pietras, S. T. Bakker, T. T. Ho, B. Gottgens, E. Passegue
This study identifies stromal inflammation as a key driver of hematopoietic aging and shows that blocking IL-1 signaling can improve hematopoietic regeneration.
bioRxiv · Mar 8, 2021 · PreprintCell Biology