Author

E. M. Pietras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:flow cytometry· 2

Frequent Co-Authors

A. Goodspeed· 2 shared J. DeGregori· 2 shared J. L. Rabe· 2 shared J. S. Chavez· 2 shared T. S. Mills· 2 shared A. Alkhani· 1 shared A. D'Alessandro· 1 shared A. Flohr Svendsen· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

A. Goodspeed

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Neonatal hepatic myeloid progenitors expand and propagate liver inflammation in mice

A. Alkhani, C. Korsholm, S. Mohamedaly, C. S. Levy, C. C. Duwaerts, E. M. Pietras, A. Nijagal

This study shows that neonatal liver inflammation in mice is driven by expanded hematopoietic progenitors, and their depletion prevents disease progression.

bioRxiv · Jun 18, 2022 · PreprintImmunology

Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease

T. S. Mills, B. Kain, M. T. Burchill, E. Danis, A. Goodspeed, R. Culp-Hill, S. Ferrara, J. R. Roede, A. D'Alessandro, K. Y. King, E. M. Pietras

The paper shows hematopoietic stem cells (HSCs) in a mouse model of chronic autoimmune disease serve as a long-term reservoir for trained immunity, with macrophages derived from them exhibiting increased inflammatory activity and reduced metabolic function.

bioRxiv · May 20, 2022 · PreprintImmunology

Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

S. Sureshchandra, C. N. Chan, J. J. Robino, L. K. Parmelee, M. J. Nash, S. R. Wesolowski, E. M. Pietras, J. E. Friedman, D. Takahashi, W. Shen, J. D. Hennebold, D. Goldman, W. Packwood, J. R. Lindner, C. T. Roberts, , O. Varlamov

This study shows that a maternal Western-style diet impairs fetal bone marrow development and causes hyperinflammation and B-cell dysfunction in fetal hematopoietic stem and progenitor cells in rhesus macaques.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

J. S. Chavez, J. L. Rabe, D. Loeffler, K. Higa, G. Hernandez, T. S. Mills, N. Ahmed, R. L. Gessner, Z. Ke, B. M. Idler, H. M. Kim, J. R. Myers, B. M. Stevens, C. T. Jordan, H. Nakajima, , E. M. Pietras

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Journal of Experimental Medicine · Apr 15, 2021Peer-reviewedImmunology

Stromal inflammation is a targetable driver of hematopoietic aging

E. V. Verovskaya, C. A. Mitchell, F. J. Calero-Nieto, A. Herault, P. D. Dellorusso, X. Wang, S. Y. Zhang, A. Flohr Svendsen, E. M. Pietras, S. T. Bakker, T. T. Ho, B. Gottgens, E. Passegue

This study identifies stromal inflammation as a key driver of hematopoietic aging and shows that blocking IL-1 signaling can improve hematopoietic regeneration.

bioRxiv · Mar 8, 2021 · PreprintCell Biology

Chronic Interleukin-1 exposure triggers selective expansion of Cebpa-deficient multipotent hematopoietic progenitors

K. C. Higa, A. Goodspeed, J. S. Chavez, V. Zaberezhnyy, J. L. Rabe, D. G. Tenen, E. M. Pietras, J. DeGregori

This study shows chronic IL-1β exposure selects for Cebpa-deficient HSPC by promoting myeloid differentiation and repressing stem cell programs, linking chronic inflammation to hematologic disorders.

bioRxiv · Mar 25, 2020Cancer Biology