Author

S. V. Leonov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. D. Vyatkin· 2 shared A. V. Belikov· 2 shared A. A. Dergalev· 1 shared A. I. Alexandrov· 1 shared D. V. Otnyukov· 1 shared E. V. Grosfeld· 1 shared I. I. Kireev· 1 shared M. D. Ter-Avanesyan· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. D. Vyatkin

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3 papers

Recent·Most cited

Comprehensive patient-level classification and quantification of driver events in TCGA PanCanAtlas cohorts

A. D. Vyatkin, D. V. Otnyukov, S. V. Leonov, A. V. Belikov

The paper classifies and quantifies driver events in TCGA PanCanAtlas cohorts, finding that chromosomal gains/losses and copy-number alterations are more prevalent than point mutations.

bioRxiv · Mar 17, 2021Cancer Biology

The Poisson process is the universal law of cancer development: driver mutations accumulate randomly, silently, at constant rate and for many decades, likely in stem cells

A. V. Belikov, A. D. Vyatkin, S. V. Leonov

The paper shows that the Erlang distribution, derived from the Poisson process, accurately models cancer incidence across all ages, suggesting driver mutations accumulate randomly and at a constant rate in stem cells.

bioRxiv · Nov 7, 2020Cancer Biology

Analysis of novel hyperosmotic shock response suggests \"beads in liquid\" cytosol structure

A. I. Alexandrov, E. V. Grosfeld, A. A. Dergalev, V. V. Kushnirov, R. N. Chuprov-Netochin, P. A. Tyurin-Kuzmin, I. I. Kireev, M. D. Ter-Avanesyan, S. V. Leonov, M. O. Agaphonov

The paper identifies a rapid cytosolic response to hyperosmotic shock involving transient protein foci, proposing a new model of cytosol structure as gel-like regions suspended in a liquid network.

bioRxiv · Feb 27, 2019Cell Biology