Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site
S. V. Molinski, V. M. Shahani, A. S. Subramanian, S. S. MacKinnon, G. Woollard, M. Laforet, O. Laselva, L. D. Morayniss, C. E. Bear, A. Windemuth
The paper maps CFTR mutations to protein structures and predicts corrector binding sites, identifying mutation clusters and a potential multi-domain binding site for Class I correctors.
bioRxiv · Jan 2, 2018Biochemistry