O. Laselva

Benchmarking organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs

This study benchmarks Trikafta's efficacy in CF patient-derived iPSC-derived colonic and airway tissues compared to isogenic controls, showing differential therapeutic responses.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site

The paper maps CFTR mutations to protein structures and predicts corrector binding sites, identifying mutation clusters and a potential multi-domain binding site for Class I correctors.