S. V. Scarpino

A family of fitness landscapes modeled through gene regulatory networks

This paper models fitness landscapes using gene regulatory networks, showing that topographical features are insensitive to fitness functions and proposing an efficient algorithm for constructing mesoscopic structures.

The Ensemble of Gene Regulatory Networks at Mutation-Selection Balance

This paper develops a quasi-species model of GRN evolution and shows that GRN frequencies at equilibrium are proportional to their eigenvector centrality in genotype networks.

Reproductive Barriers as a Byproduct of Gene Network Evolution

This study develops a network-based model to show reproductive barriers can arise rapidly between populations due to genetic interactions in gene regulatory networks.

Topological features of gene regulatory networks predict patterns of natural diversity in environmental response

The paper examines gene regulatory network topology in Arabidopsis thaliana to predict patterns of genetic variation in response to drought and cold stress.