C.-H. Yang

Developmental priming of cancer susceptibility

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Serum amyloid A3 deficiency modulates aortic immune composition and attenuates murine atherosclerosis progression

This study shows that Saa3 deficiency reduces atherosclerosis in mice by altering aortic immune cell composition and function.

Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation

This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Characterization of a novel estrogen- and progesterone-responsive endometrial cancer cell line: HCI-EC-23

This paper introduces a new endometrial cancer cell line, HCI-EC-23, which responds to estrogen and progesterone, and shows it has similar estrogen-responsive gene regulation to Ishikawa cells.

A family of fitness landscapes modeled through gene regulatory networks

This paper models fitness landscapes using gene regulatory networks, showing that topographical features are insensitive to fitness functions and proposing an efficient algorithm for constructing mesoscopic structures.

Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 Diabetes

This study shows that increased neuropeptide Y1 receptor signaling contributes to β-cell dysfunction in type 2 diabetes and that inhibiting this receptor with BIBO3304 improves β-cell function and glycaemic control.

The Ensemble of Gene Regulatory Networks at Mutation-Selection Balance

This paper develops a quasi-species model of GRN evolution and shows that GRN frequencies at equilibrium are proportional to their eigenvector centrality in genotype networks.

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation

The paper determines the structure of a transient rPTPε and phospho-Src complex using integrative methods, showing a distal interaction site and a mutation-induced disruption of binding.

PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

This study identifies PELP1/SRC-3-dependent regulation of metabolic kinases as a driver of therapy-resistant ER+ breast cancer and shows that targeting PFKFBs can block tumorsphere formation in resistant models.

Reproductive Barriers as a Byproduct of Gene Network Evolution

This study develops a network-based model to show reproductive barriers can arise rapidly between populations due to genetic interactions in gene regulatory networks.

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Cell-length heterogeneity: a population-level solution to growth/virulence trade-offs in the plant pathogen Dickeya dadantii

This study shows that Dickeya dadantii uses cell-length heterogeneity to balance virulence and growth during infection, with short cells being virulent and filamentous cells supporting rapid growth.

Thermopneumatic suction integrated microfluidic blood analysis system

This paper presents a microfluidic blood separation system that efficiently isolates plasma with 99.7% accuracy in 6 minutes using thermopneumatic suction.

Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancer

The paper investigates the interaction between glucocorticoid receptor (GR) and estrogen receptor α (ER) in endometrial cancer, finding that GR expression correlates with poor prognosis and that their combined activity alters gene expression and genomic binding.