ImmunologybioRxiv
Antigen Presentation-Independent Reciprocal Immune Modulation by HLA-DRB1 Allelic Epitopes that Associate with Autoimmune Disease Risk or Protection
V. van Drongelen, B. Miglioranza Scavuzzi, S. Veloso Nogueira…·J. Holoshitz
The paper shows HLA-DRB1 alleles influence macrophage polarization independently of antigen presentation, affecting inflammatory responses linked to autoimmune disease risk or protection.
DOI 10.1038/s41598-021-82195-3