Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma
A. Mikulasova, C. Ashby, R. G. Tytarenko, P. Qu, A. Rosenthal, J. A. Dent, K. R. Ryan, M. A. Bauer, C. P. Wardell, A. Hoering, K. Mavrommatis, M. Trotter, S. Deshpande, S. Yaccoby, E. Tian, , B. A. Walker
The paper identifies MYC rearrangements in multiple myeloma, showing they are complex and linked to overexpression of MYC and PVT1 through distinct DNA repair mechanisms.
bioRxiv · Jun 24, 2019Cancer Biology