Characterization of norbelladine synthase and noroxomaritidine/norcraugsodine reductase reveals a novel catalytic route for the biosynthesis of Amaryllidaceae alkaloids including the Alzheimer's drug galanthamine
B. B. Majhi, S.-E. Gelinas, N. Merindol, I. Desgagne-Penix
The paper characterizes two enzymes involved in the biosynthesis of Amaryllidaceae alkaloids, showing they work together to produce norbelladine, a precursor to the Alzheimer's drug galanthamine.
bioRxiv · Jul 30, 2022 · PreprintBiochemistry