Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM
M.-E. Maeots, B. Lee, A. Nans, S.-G. Jeong, M. M. N. Esfahani, D. J. Smith, C.-S. Lee, S. S. Lee, M. Peter, R. I. Enchev
This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.
Nature Communications · Jul 10, 2020Peer-reviewedBiochemistry