S. S. Lee

Distributable, Metabolic PET Reporting of Tuberculosis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

At matched loads, aging does not alter ankle, muscle, or tendon stiffness

This study finds that aging does not change muscle or tendon stiffness at matched loads but reduces stiffness at matched effort due to decreased strength.

Synthetic Biodegradable Void-forming Hydrogels for In Vitro 3D Culture of Functional Human Bone Cell Networks

This paper introduces a synthetic biodegradable hydrogel for 3D culture of human bone cells and analysis of secreted ECM, demonstrating rapid network formation and microfluidic integration.

Evolutionarily related host and microbial pathways regulate fat desaturation

This study identifies how host and microbial pathways regulate fat desaturation through shared signaling mechanisms in C. elegans.

Hybrid machine-learning framework for volumetric segmentation and quantification of vacuoles in individual unlabeled yeast cells using holotomography

This paper develops a hybrid machine-learning framework to segment and quantify vacuoles in unlabeled yeast cells using holotomography data.

A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

This paper develops a self-renewing biomimetic skeletal muscle construct using induced myogenic progenitor cells that recapitulates myogenic differentiation and repair.

3D-Printed LEGO(R)-inspired Titanium Scaffolds for Patient-Specific Regenerative Medicine

This paper presents a 3D-printed titanium scaffold that can be manually assembled to fit patient-specific defects, improving mechanical properties and cellular activity through porous structures and surface treatment.

Developing Wolbachia-based disease interventions for an extreme environment

This study evaluates Wolbachia strains in Saudi Arabian mosquitoes for dengue suppression in extreme environments, finding reduced heat tolerance and local adaptation effects.

Specialization of chromatin-bound nuclear pore complexes promotes yeast aging

This study shows that DNA circles in yeast cells alter NPC composition, leading to aging by triggering NPC specialization.

Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

This paper determines the structures of DPAGT1 with substrates and inhibitors, revealing catalytic mechanisms and disease-causing mutations, and designs non-toxic antibiotics for tuberculosis.