Thermodynamic analysis of point mutations inhibiting high-temperature reversible oligomer of PDZ3
T. Saotome, T. Mezaki, B. Subbaian, S. Unzai, J. C. Martinez, S.-i. Kidokoro, Y. Kuroda
The paper shows that mutating hydrophobic residues at the PDZ3 oligomeric interface inhibits high-temperature reversible oligomerization, as evidenced by DSC analysis showing a single endothermic peak.
Biophysical Journal · Oct 1, 2020Peer-reviewedBiophysics