Proteome birthdating reveals age-selectivity of protein ubiquitination
M. E. Meadow, S. Broas, M. Hoare, F. Alimohammadi, K. A. Welle, K. Swovick, J. R. Hryhorenko, J. C. Martinez, S. A. Biashad, A. Seluanov, V. Gorbunova, A. Buchwalter, S. Ghaemmaghami
This study introduces proteome birthdating to measure protein age and finds that ubiquitinated proteins are predominantly newly synthesized, with distinct age distributions across cellular pathways.
bioRxiv · Oct 8, 2023Biochemistry