Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis
Y. Ai, C. Guo, M. Garcia-Contreras, L. S. Sanchez, A. Saftics, O. Shodubi, S. Raghunandan, J. Xu, S.-J. Tsai, Y. Dong, R. Li, T. Jovanovic-Talisman, S. Gould
This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.
bioRxiv · May 26, 2023Cell Biology